[Combined effects of chemicals on rat hepatic microsomal monooxygenases: 1. Combination of polychlorinated biphenyls and di-(2-ethylhexyl)phthalate] | Health & Environmental Research Online (HERO)

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HERO ID

1334204

Reference Type

Journal Article

Title

[Combined effects of chemicals on rat hepatic microsomal monooxygenases: 1. Combination of polychlorinated biphenyls and di-(2-ethylhexyl)phthalate]

Author(s)

Takabatake, E; Yamada, S

Year

1980

Is Peer Reviewed?

Journal

Eisei Kagaku / Journal of Hygienic Chemistry
ISSN: 0013-273X

Volume

Issue

Page Numbers

247-253

Language

Japanese

DOI

10.1248/jhs1956.26.247

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0019129050&doi=10.1248%2fjhs1956.26.247&partnerID=40&md5=607f40aaf93c1fdd3395b021c5f01852
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Abstract

Combined effects of polychlorinated biphenyls (PCB) and di-(2-ethylhexyl) phthalate (DEHP) on rat hepatic microsomal monooxygenases were investigated in 16 dose-groups consisting of 4 PCB-doses (0, 20, 67 and 200 mg/kg) and 4 DEHP-doses (0, 1, 3.3 and 10 g/kg). Additive or synergistic interaction between PCB and DEHP was estimated by analysis of variance using orthogonal polynomials and by deviation from parallelism among dose-response curves. Combined effects of PCB and DEHP on liver weight and aminopyrine N-demethylase were additive and effect on cytochrome P-450 was synergistic. Aniline hydroxylase was induced only by PCB.