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1015662 
Journal Article 
Genotoxic potential of arsenic at its reference dose 
Kesari, VP; Kumar, A; Khan, PK 
In Press 
Yes 
Ecotoxicology and Environmental Safety
ISSN: 0147-6513
EISSN: 1090-2414 
80 
126–131 
English 
Arsenic, a highly hazardous contaminant in our drinking water, accounts for various toxic effects (including cancer) in human. However, intake of arsenic @0.3μgkg(-1)day(-1) through drinking water, containing arsenic at its guideline value or maximum contaminant limit (10μgL(-1)), has been estimated to pose very little or no measurable risk to cancer in humans. The value also appears to be equal to the human reference dose (or index dose) of arsenic based on human skin toxicity data. The present work was a quantitative assessment of the genotoxic potential of arsenic in mice at doses equivalent to its human reference dose as well as its multiples. Significant increases in the frequencies of chromosome abnormalities in the bone marrow cells were registered over the control level upon exposure to all the doses of arsenic including its reference dose (or index dose). The assessment of arsenic genotoxicity in humans at low doses will therefore be highly instrumental in establishing a permissible limit of arsenic in drinking water. 
Arsenic genotoxicity; Chromosome abnormality; Guideline value; Index dose; Maximum contaminant limit; Reference dose 
• Arsenic Hazard ID
     1. Initial Lit Search
          PubMed
          WOS
          ToxNet
          WOS
          Considered New
     2. Lit Search Updates through Oct 2015
          WOS
          Considered
     4. Considered through Oct 2015
     5. Additions through Oct 2015
     6. Cluster Filter through Oct 2015
     7. Other Studies through Oct 2015
          MOA
• Arsenic (Inorganic)
     1. Literature
          PubMed
          Toxline, TSCATS, & DART
          Web of Science
          Lit search updates through Oct 2015
     3. Hazard ID Screening
          Other potentially supporting studies
     4. Adverse Outcome Pathways/Networks Screening
          Relevant
• Arsenic MOA
     4. Adverse Outcome Pathways
          Non-oxidative DNA/ chromosomal damage
     1. MOA Literature Screening
          Health Effect Screening
• Arsenic Susceptibility
     Life Stages Citation Mapping
          20%-25%