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HERO ID
1239588
Reference Type
Journal Article
Title
Chronic toxicity and carcinogenic evaluation of diisononyl phthalate in rats
Author(s)
Lington, AW; Bird, MG; Plutnick, RT; Stubblefield, WA; Scala, RA
Year
1997
Is Peer Reviewed?
Yes
Journal
Fundamental and Applied Toxicology
ISSN:
0272-0590
EISSN:
1095-6832
Publisher
ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
Location
SAN DIEGO
Volume
36
Issue
1
Page Numbers
79-89
Language
English
PMID
9073470
DOI
10.1093/toxsci/36.1.79
Web of Science Id
WOS:A1997WP30200009
URL
http://www.sciencedirect.com/science/article/pii/S0272059097922867
Exit
Relationship(s)
has other version or edition
1065989
Chronic toxicity/oncogenicity study in F-344 rats (final report) with cover letter dated 042386
is related to other part(s)
1325509
Chronic feeding study in Fisher 344 rats (final pathology report) with cover letter dated 042386
Abstract
Groups of 110 Fischer 344 rats/sex were fed diisononyl phthalate (DINP) at dietary levels of 0, 0.03, 0.3, and 0.6 wt% for periods up to 2 years. Interim sacrifices of 10 predesignated rats/sex/dose were at 6, 12, and 18 months with surviving animals sacrificed at 24 months. At study termination, survival was in excess of 60% for every group. At the mid or high dose, the following biological effects were noted: slight decreases in food consumption and body weight; slight increase in mortality; a dose-related increase in relative organ weights of liver and kidney; and some slight effects on urinalysis, hematologic, and clinical chemistry parameters. No peroxisome induction was observed in livers of treated rats compared with controls. No clear treatment-related nonneoplastic or neoplastic lesions were found. However, mononuclear cell leukemia (MNCL) and changes known to be associated with an increased incidence of MNCL were seen in the mid-dose and high-dose groups. A literature review suggests that MNCL is a common finding in aging F344 rats and that this increased incidence in rats treated with DINP is not relevant to man. A clear no-observed-effect level was demonstrated for all biological end points at a dietary level of 0. 03 wt% or approximately 17 mg/kg/day of DINP.
Keywords
Phthalic Acids; diisononyl phthalate; 4010KIX4CK; Index Medicus; Testis -- drug effects; Body Weight -- drug effects; Blood Chemical Analysis; Administration, Oral; Rats, Inbred F344; Spleen -- drug effects; Survival Rate; Hematologic Tests; Precancerous Conditions -- pathology; Carcinogenicity Tests; Adrenal Glands -- drug effects; Microbodies -- drug effects; No-Observed-Adverse-Effect Level; Animals; Urine -- chemistry; Leukemia, Experimental -- pathology; Leukemia, Experimental -- chemically induced; Organ Size -- drug effects; Spleen -- pathology; Adrenal Glands -- pathology; Liver -- drug effects; Kidney -- pathology; Kidney -- drug effects; Phthalic Acids -- toxicity; Liver -- pathology
Tags
•
Diisononyl Phthalate (DINP)
Literature Search
LitSearch May 2013
PubMed
Web of Science
Toxline
Studies with Health Effects Data
Animal toxicology studies
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
Excluded
Source – no date limit through June 2013 (Private)
Pubmed
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