US EPA

1332580 

Journal Article 

Ethanol production in a microporous hollow-fiber-based extractive fermentor with immobilized yeast 

Kang, W; Shukla, R; Sirkar, KK 

1990 

Yes 

Biotechnology and Bioengineering
ISSN: 0006-3592
EISSN: 1097-0290 

36 

8 

826-833 

English 

18597281 

10.1002/bit.260360812 

https://search.proquest.com/docview/15724248?accountid=171501
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Microporous-membrane-based extractive product recovery in product-inhibited fermentations allows in situ recovery of inhibitory products in a nondispersive fashion. A tubular bioreactor with continuous strands of hydrophobic microporous hollow fibers having extracting solvent flowing in fiber lumen was utilized for yeast fermentation of glucose to ethanol. Yeast was effectively immobilized on the shell side in small lengths of chopped microporous hyrophilic hollow fibers. The beneficial effects of in situ dispersion-free solvent ex (oleyl alcohol and dibutyl phthalate) were demonstrated for a 300 g/L glucose substrate feed. Outlet glucose concentration dropped drastically from 123 to 41 g/L as solvent/ substrate flow ratio was increased from 0 to 3 at 9 mL/h of substrate flow rate with oleyl alcohol as extracting solvent. The significant productivity increase with in situ solvent extraction became more evident as solvent/ substrate flow ratio increased. A model of the locally integrated extractive bioreactor describes the observed fermentor performance quite well. 

immobilized cells; fermenters; fermentation; ethanol; olelyl alcohol; n-butyl phthalate