Developmental effects of dioxins and related endocrine disrupting chemicals | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

150745

Reference Type

Journal Article

Subtype

Review

Title

Developmental effects of dioxins and related endocrine disrupting chemicals

Author(s)

Birnbaum, LS

Year

1995

Is Peer Reviewed?

Journal

Toxicology Letters
ISSN: 0378-4274
EISSN: 1879-3169

Volume

Issue

Page Numbers

743-750

Language

English

PMID

8597137

DOI

10.1016/0378-4274(95)03592-3

Web of Science Id

WOS:A1995TU51400107

Relationship(s)

is also published as 2192691 Developmental effects of dioxins and other endocrine disrupting chemicals

Abstract

Alteration of hormones has long been known to affect development. TCDD and related PHAHs modulate the levels of many hormonal systems. Dioxins cause a spectrum of morphological and functional developmental deficits. Fetotoxicity, thymic atrophy, and structural malformations are often noted. Delayed genitourinary tract effects have been observed, and recent studies reported behavioral effects. Highly exposed human offspring have exhibited developmental problems as well. Recently, hormonal and neurological abnormalities have been reported in infants from the general population. The complex alteration of multiple endocrine systems is likely associated with the spectrum of adverse developmental effects caused by dioxin and related compounds.

Keywords

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD); Dioxins; Polychlorinated biphenyls (PCBs); Developmental toxicity; Endocrine disruption; Receptor-mediated toxicity

Conference Name

International Congress of Toxicology - VII