Hypoactivity in adolescent monkeys perinatally exposed to PCBs and hyperactive as juveniles | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

201796

Reference Type

Journal Article

Title

Hypoactivity in adolescent monkeys perinatally exposed to PCBs and hyperactive as juveniles

Author(s)

Bowman, RE; Heironimus, MP

Year

1981

Is Peer Reviewed?

Journal

Neurobehavioral Toxicology and Teratology
ISSN: 0275-1380

Volume

Issue

Page Numbers

15-18

Language

English

Web of Science Id

WOS:A1981LN38300004

Abstract

A group of three rhesus monkeys (M. mulatta) whose mothers had been fed 2.5 ppm PCBs (Aroclor 1248) in their diets through gestation and three months of nursing were tested for locomotor activity at 44 months of age. These animals had been hyperactive relative to controls at six and twelve months of age but were significantly hypoactive when compared to the same group of controls in the same apparatus in the 44-month test. Both groups showed within-session activity declines suggestive of reactivity which did not differ significantly between groups either within sessions or in their adaptation over the course of testing. This phenomenon represents a clear-cut delayed and possibly permanent effect of the early PCB exposure.