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Tags
HERO ID
2088478
Reference Type
Journal Article
Title
Sub-microscopic gametocyte carriage in febrile children living in different areas of Gabon
Author(s)
Mawili-Mboumba, DP; Nikiéma, R; Bouyou-Akotet, MK; Bahamontes-Rosa, N; Traoré, A; Kombila, M
Year
2013
Is Peer Reviewed?
1
Journal
Malaria Journal
ISSN:
1475-2875
EISSN:
14752875
Volume
12
Page Numbers
375
Language
English
PMID
24168323
DOI
10.1186/1475-2875-12-375
Web of Science Id
WOS:000329102500001
Abstract
BACKGROUND:
Considering malaria prevalence declines in parts of sub-Saharan Africa, such as Gabon, identification of the human infectious reservoir is important for successful malaria control. Microscopic and sub-microscopic parasites contribute to malaria transmission. The aim of the present study was to evaluate the proportion of microscopic and sub-microscopic gametocyte carriers among febrile patients in two different areas of Gabon.
METHODS:
Samples from febrile children aged less than 11 years old were collected from February 2008 to January 2009 at two health centres of Gabon. Patients were screened for the presence of asexual Plasmodium falciparum parasites. Gametocyte carriage was determined by microscopy and QT-NASBA.
RESULTS:
Gametocytes were detected in 5.3% (n = 16/304) of children by microscopy compared to 45.7% (n = 139/304) by QT-Nasba. Sub-microscopic gametocyte carriage (ie microscopy negative and QT-Nasba positive) was found in 89.2% (n = 124/139) of patients. Among patients with microscopically detected trophozoites, the proportion of sub-microscopic gametocyte (SMG) carriers was 58.4% (n = 118/202) and 6% in samples from children with negative slides (p < 0.01). In Oyem, where malaria prevalence is three-fold higher than in Owendo, SMG carriage was more frequent (49.0% vs 32.6% in Owendo; p < 0.01).
CONCLUSION:
Sub-microscopic gametocytaemia is common among Gabonese febrile children. They might strongly contribute to maintain malaria transmission. However, further analysis of sub-microscopic parasite carriage among asymptomatic individuals will be helpful to better characterize malaria transmission.
Tags
IRIS
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
3. Hazard ID Screening
Other potentially supporting studies
•
Inorganic Arsenic (7440-38-2) [Final 2025]
PubMed
Considered New
2. Lit Search Updates through Oct 2015
PubMed
Considered
7. Other Studies through Oct 2015
Non-Arsenic
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