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HERO ID
2149154
Reference Type
Journal Article
Title
Effect of selenomethionine supplementation in food on the excretion and toxicity of arsenic exposure in female mice
Author(s)
Rodríguez-Sosa, M; García-Montalvo, EA; Del Razo, LM; Vega, L
Year
2013
Is Peer Reviewed?
Yes
Journal
Biological Trace Element Research
ISSN:
0163-4984
EISSN:
1559-0720
Volume
156
Issue
1
Page Numbers
279-287
Language
English
PMID
24218229
DOI
10.1007/s12011-013-9855-9
Web of Science Id
WOS:000327897800034
URL
http://link.springer.com/10.1007/s12011-013-9855-9
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Abstract
Selenium (Se) is an essential component of several major metabolic pathways and controls immune function. Arsenic (As) is a human carcinogen with immunotoxic and genotoxic activities, functioning mainly by producing oxidative stress. Due to the ability of Se to interact with As and to possibly block its toxic effects, we investigated the impact of dietary Se-methionine (Se-Met) supplementation on the toxicity of As exposure in vivo in a mouse model. Sufficient and excess levels of Se-Met (0.2 and 2 ppm, respectively) were fed to C57BL/6N female mice exposed to sodium arsenite (3, 6 and 10 mg/kg) in tap water for 9 days. We observed that As exposure increased Se-Met excretion in the urine. Se-Met supplementation increased the relative liver weight and decreased the concentration of total liver proteins in animals exposed to 10 mg/kg of As. Se-Met supplementation maintained a normal pool of glutathione in the liver and increased glutathione peroxidase concentration, although the lipoperoxidation level was increased by Se-Met even without As exposure. Se-Met supplementation helped to maintain the CD4/CD8 ratio of lymphocytes in the spleen, although it increased the proportion of B cells. Se-Met supplementation prior to As exposure increased the secretion of interleukin-4, IL-12 and interferon-γ and the stimulation index of the spleen cells in in vitro assays. Se-Met intake improved the basal immunological parameters but did not reduce the damage caused by oxidative stress after low-dose As exposure.
Keywords
Immunomodulation; Proliferative responses; Cytokines; Glutathione; Oxidative stress
Tags
•
Arsenic Hazard ID
PubMed
Considered New
PubMed
WOS
ToxNet
Considered New
2. Lit Search Updates through Oct 2015
PubMed
WOS
ToxNet
Considered
7. Other Studies through Oct 2015
Episodic exposure/acute exposure
PBPK/TK
Susceptibility Category
Nutritional Deficiencies (includes socioeconomic status & BMI)
Health Effect Category
Liver effects
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
3. Hazard ID Screening
Other potentially supporting studies
5. Susceptibility Screening
Relevant
Animal
•
Arsenic Susceptibility
4. Susceptibility and Lifestages
Nutritional deficiencies (includes socioeconomic status and BMI)
5. Health Effect
Liver Effects
1. Susceptibility Literature Screening
Keyword Search
Life Stages Citation Mapping
15%-20%
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