US EPA

2167057 

Journal Article 

Metabolic fate of 3H 2,5,2',5'-tetrachlorobiphenyl in infant nonhuman primates 

Hsu, IC; Vanmiller, JP; Allen, JR 

1975 

Yes 

Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 

14 

2 

233-240 

English 

809075 

10.1007/BF01701320 

WOS:A1975AQ10600018 

The metabolic fate of (3H) 2,5,2',5'-tetrachlorobiphenyl (1336363) (TCB) in infant nonhuman primates was investigated because the primate is far more susceptible to the toxic effects produced by polychlorinated-biphenyls (PCBs) than the rat. It was considered important to evaluate the metabolic fate, site of localization, and excretion rate of the PCB isomers in the primate. Four monkeys of the experimental group were given a single dose of tritiated TCB dissolved in 1.5ml of corn oil by gastric intubation. Feces and urine were collected at 24 hour intervals. It was determined that the metabolic fate of TCB in the infant primate was decidedly different than in the rat. At 72 hours a large percentage of the TCB was retained in the body in an unmetabolized form and was primarily associated with the serum proteins and cellular macromolecules. That portion of the TCB excreted in the urine was metabolized to dihydro-TCB diol which is not the case in rats. It is concluded that the high specific activity of radioactive labeled material in the adrenal gland and skin of the monkeys in this experiment is noteworthy because acne, skin lesions, and disturbance of steroid hormone metabolism, which occur in long term experiments may relate to the localization of TCB in those tissues.