US EPA

2174833 

Journal Article 

Effects of a polychlorinated biphenyl, kanechlor-400, on intestinal solute transport and fluid transfer in mice 

Madge, DS 

1979 

Yes 

General Pharmacology
ISSN: 0306-3623
EISSN: 1879-0011 

10 

3 

183-188 

English 

112001 

10.1016/0306-3623(79)90086-7 

WOS:A1979HA38100005 

1. 1. Using the mouse everted entire small intestine, the absorption of d-glucose apparently decreased 7 days after a single oral dose (3.0 g kg −1 body wt) of a commercial polychlorinated biphenyl, Kanechlor 400. Tissue accumulation of the solute during the experiments decreased slightly. The effects were related to both time and dosage. 2. 2. The absorption of d-galactose and l-histidine and solute tissue accumulation remained unaltered in treated animals. 3. 3. Other experiments suggested that the malabsorptive effects of d-glucose in treated animals probably resulted from increased metabolism of the intestinal tissues during the absorption process. 4. 4. Fluid transfer remained unchanged, as did the body-weight. The histology of the tissues was little altered. The liver increased in weight. 5. 5. These results were compared with similar investigations using other polychlorinated biphenyls and terphenyls and their toxic contaminants.