Stimulation of hepatic drug hydroxylation and conjugation by a cutaneously applied PCB-mixture (Clophen-A-50) | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2175303

Reference Type

Journal Article

Title

Stimulation of hepatic drug hydroxylation and conjugation by a cutaneously applied PCB-mixture (Clophen-A-50)

Author(s)

Marniemi, J; Nokkala, M; Vainio, H; Hartiala, KJW

Year

1977

Is Peer Reviewed?

Yes

Journal

Chemico-Biological Interactions
ISSN: 0009-2797
EISSN: 1872-7786

Volume

Issue

Page Numbers

247-251

Language

English

PMID

408019

DOI

10.1016/0009-2797(77)90011-4

Web of Science Id

WOS:A1977DV84200011

Abstract

The present study was carried out to investigate the effects of small amounts of a commercial PCB (polychlorinated biphenyls) (environmental contaminants) mixture (Clophen A 50) administered via the skin, on epoxide hydrase and glucuronide and glutathione conjugation of the (rat) liver, compared to effects of monooxygenase. Even cutaneously applied small doses of PCB mixtures easily reach the liver at concentrations high enough to induce besides the monooxygation step, also the subsequent epoxide hydration and glucuronide and glutathione conjugation steps of drug metabolism.