US EPA

2177492 

Journal Article 

Accumulation and excretion of isopropylchlorobiphenyls in mouse and fish 

Sugiura, K; Mase, T; Imasaki, K; Goto, M 

1981 

Yes 

Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 

26 

1 

46-53 

English 

6784797 

10.1007/BF01622053 

WOS:A1981LD78400009 

Many papers are available on the metabolic conversion of polychlorinated biphenyls (PCBs) in animals and microorganisms, and the dominant metabolites are shown to be hydroxylated compounds and their conjugates (a review; Sundstrom et al. 1976). In the case of isopropylchlorobiphenyls, they are metabolized along two major routes; one pathway proceeds by stepwise oxidation of the isopropyl group to chlorobiphenyl carboxylic acid, and the other by hydroxylation of the chlorine substituted phenyl ring (Tulp et al. 1977a, 1978). Since metabolism is facilitated by the presence of an alkyl group attached to the aromatic ring, isopropylchlorobiphenyls are thought to be less persistent and accumulative than PCBs.
In order to estimate the influence of metabolism on accumulation and excretion of lipophilic compounds, the residual behaviours of 4-chloro-4'-isopropyl-, 3,5-dichloro-4'-isopropyl-, 4,4'-dichloro- and 3,5,3',5'-tetrachloro-biphenyl were compared in mouse and fish by using an internal standard method.