US EPA

2178158 

Journal Article 

Effect of age and sex on liver response to phenoclor DP65 a polychlorinated biphenyl, in rat 

Narbonne, JF 

1978 

Yes 

Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 

20 

5 

662-667 

English 

104754 

10.1007/BF01683581 

WOS:A1978FX08300015 

has other version or edition 1405902 Effects of age and sex on liver responses to Phenoclor DP6, a polychlorinated biphenyl, in the rat

Many metabolic adaptations are necessary for the survival of an animal when administered PCBs in diet (Daubeze 1977). In PCB treated rats, increase in liver weight (Litterst et al. 1972, Bruckner et al. 1973, Kimura and Baba 1973) and microsomal protein content (Bruckner et al. 1973, Turner and Green 1974), liver smooth endoplasmic reticulum proliferation (Nishizumi 1970), enhanced microsomal oxygenase activity (Bruckner et al 1974, Litterst and Van Loon 1974), and fatty infiltration of the liver (Nishizumi 1970, Kimura and Baba 1973) were promptly observed. When rats were fed diets containing Phenoclor OP6 (French PCB PRODELEC-FRANCE) the same effects were noted (Daubeze 1977, Narbonne and Gillet 1977), Furner et al. (1969) showed that age and sex influence the action of drug treatment on the induction of drug metabolism enzymes. Moreover Allen et al. [1974) indicate that proteosynthesis was enhanced in young rats.

Previous work (Narbonne 1976) demonstrated that the principal response of liver to DP6 treatment consisted in increased proteosynthesis. This observation suggested a difference in reactions between male and female rats and between young and adult rats to PCB treatment. However, Grant and Phillips (1974) showed that sex and age had very little effect on the toxicity of Aroclor 1254 in rats. Because of the difference in the toxicity between Aroclor and Phenoclor (Peakall 1972), studies were undertaken to determinate the effect of age and sex on rat liver response to Phenoclor DP6 treatment.