US EPA

2178588 

Journal Article 

Organochlorine compounds in neoplastic and adjacent apparently normal gastric mucosa 

Wassermann, M; Nogueira, DP; Cucos, S; Mirra, AP; Shibata, H; Arie, G; Miller, H; Wassermann, D 

1978 

Yes 

Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 

PESTAB/79/0514 

20 

4 

544-553 

English 

102387 

PESTAB. Samples of malignant tissue were studied along with apparently normal samples for the presence of organochlorine compounds. The normal tissue examined was taken from areas adjacent to the cancerous growths, in the gastric mucosa. The concentration of total DDT in the extracted lipids of the gastric carcinoma samples was higher than in those of the adjacent apparently normal gastric mucosa, 16.74 and 10.39 ppm, respectively. Total p,p'-DDT was higher (13.16 ppm) in extracted lipids of the tumoral tissues than in adjacent gastric mucosa (7.69 ppm). The level of gamma-BHC and dieldrin was higher in the extracted lipids of the gastric mucosa in comparison with the epiploon and the abdominal adipose tissue. The concentration of hexachlor epoxide was lower in the extracted lipids of the tumoral tissue than in adjacent gastric mucosa, 0.11 vs 0.59 ppm, respectively. The highest levels of PCB's stored were in the extracted lipids of tumoral tissue with a significant difference between this value of 15.33 and the value of 6.29 ppm for the adjacent gastric mucosa samples.