US EPA

2179941 

Journal Article 

Metabolism of low oral doses of DDT and DDE by tame mule deer fawns 

Watson, M; Pharoah, B; Wyllie, J; Benson, WW 

1975 

Yes 

Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 

PESTAB/75/1644 

13 

3 

316-323 

English 

1125459 

https://search.proquest.com/docview/45791254?accountid=171501
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PESTAB. The metabolism of orally administered DDT and DDE in two captive fawn mule deer, Odocoileus heminonus, was determined. Deer 1 was given one 5 mg DDE cube daily. Deer 2 received a 5 mg DDT cube daily. Doses were maintained for a total of 30 days for both animals. In deer 1, serum DDE levels increased rapidly as the dosing period progressed, reaching a plateau of about 14 ppb midway through the period and falling to below 5 ppb 8 days after doses had ceased. Levels of DDT increased briefly early in the dosing period, after which no DDT was detected until well after pesticide doses had stopped. No DDD (TDE) was found in the serum until after doses had stopped; no DDT was detected at any time. Serum DDE was not detected in deer 2, nearly equal quantities of DDT and TDE were present. Levels of DDT reached a plateau quickly at 3.5 ppb, while TDE levels were slightly lower. Serum levels of both residues decreased abruptly within 4 days after doses had been stopped, but both substances experienced a brief increase again 2 wk later. No DDT was detected. Fecal pesticides in deer 1 were similar to serum. In contrast to serums from deer 2, fecal pesticides from this animal contained much greater levels of TDE than of DDT. 

article; Animals; Dichlorodiphenyl Dichloroethylene; Dichlorodiphenyldichloroethane; Isomerism; Time Factors; pesticides