US EPA

2180176 

Journal Article 

DDT association with glucose-6-phosphate dehydrogenase 

Keil, JE; Croft, HW; Sandifer, SH 

1974 

Yes 

Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 

PESTAB/75/0125 

12 

3 

343-345 

English 

4433878 

PESTAB. A pilot study was conducted to examine the association between serum DDT levels and an easily measured genetic marker, glucose-6-phosphate dehydrogenase, a red cell enzyme assisting in maintaining cell wall integrity. Deficiency of this enzyme is shown by intermittent anemia. The study included 16 pre-adolescent Black youths. DDT levels for the group ranged from 9 to 158 ppb; glucose-6-phosphate dehydrogenase levels ranged from 10-111 units. Most of the low enzyme levels occurred in the male subjects. A striking correlation was noted between total DDT and glucose-6-phosphate dehydrogenase. The p,p' isomer of DDT showed a slightly stronger association. The correlation coefficient was high but not statistically significant for the o,p'- isomer or the DDE metabolite. This evidence links DDT burdens with genetic makeup.