Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
2215401
Reference Type
Journal Article
Title
Dietary phthalates and low-grade albuminuria in US children and adolescents
Author(s)
Trasande, L; Sathyanarayana, S; Trachtman, H
Year
2014
Is Peer Reviewed?
Yes
Journal
Clinical Journal of the American Society of Nephrology
ISSN:
1555-9041
EISSN:
1555-905X
Volume
9
Issue
1
Page Numbers
100-109
Language
English
PMID
24178978
DOI
10.2215/CJN.04570413
Web of Science Id
WOS:000329364700015
URL
https://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.04570413
Exit
Abstract
BACKGROUND:
Low-grade albuminuria is an indicator of endothelial dysfunction and is associated with an increased risk of cardiovascular disease. A graded level of exposure to bisphenol A was recently identified to be associated with increased risk of low-grade albuminuria in children and adults. Because bisphenol A and phthalates coexist as dietary contaminants, this study investigated whether exposure to phthalates is also associated with low-grade albuminuria.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:
Data were examined from 667 children who participated in the 2009-2010 National Health and Nutrition Examination Survey and who had results for urinary phthalate metabolites and albumin excretion. Urinary albumin and creatinine concentrations were measured in a first morning specimen using a solid-phase fluorescent immunoassay and a Roche/Hitachi Modular P Chemistry Analyzer with an enzymatic method, respectively. Phthalate metabolites were analyzed in a separate spot urine sample from each participant, using high-performance liquid chromatography and tandem mass spectroscopy.
RESULTS:
For each (roughly) 3-fold increase in metabolites of di-2-ethylhexylphthalate (a high molecular weight phthalate commonly found in foods), a 0.55 mg/g increase in albumin/creatinine ratio (ACR) was identified (P=0.02), whereas a 1.30-fold odds of a higher ACR quartile was also identified for each (roughly) 3-fold increase (P=0.02). Higher ACR was not identified in relationship to metabolites of lower molecular phthalates commonly found in lotions or shampoos, suggesting specificity.
CONCLUSIONS:
Although reverse causation and unmeasured confounders represent alternative explanations, these findings, in conjunction with our earlier data on bisphenol A, indicate that a wide array of environmental toxins may adversely affect albuminuria and potentially increase the risk of cardiovascular disease. In view of the potential long-term health implications of ongoing exposure in this vulnerable subpopulation, our data support both further study and renewed regulatory efforts to limit exposure during childhood.
Tags
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Included
DEHP
DiNP
DiDP
Source - Dec 2013 Update (Private)
Pubmed
Source - Jun 2014 Update (Private)
Pubmed
WOS
Source – Dec 2014 Update (Private)
Pubmed
WOS
Source – Mar 2015 Update (Private)
WOS
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity