US EPA

2278615 

Journal Article 

Gut microbiome phenotypes driven by host genetics affect arsenic metabolism 

Lu, K; Mahbub, R; Cable, PH; Ru, H; Parry, NMA; Bodnar, WM; Wishnok, JS; Styblo, M; Swenberg, JA; Fox, JG; Tannenbaum, SR 

2014 

Yes 

Chemical Research in Toxicology
ISSN: 0893-228X
EISSN: 1520-5010 

27 

2 

172-174 

English 

24490651 

10.1021/tx400454z 

WOS:000331591400003 

Large individual differences in susceptibility to arsenic-induced diseases are well-documented and frequently associated with different patterns of arsenic metabolism. In this context, the role of the gut microbiome in directly metabolizing arsenic and triggering systemic responses in diverse organs raises the possibility that gut microbiome phenotypes affect the spectrum of metabolized arsenic species. However, it remains unclear how host genetics and the gut microbiome interact to affect the biotransformation of arsenic. Using an integrated approach combining 16S rRNA gene sequencing and HPLC-ICP-MS arsenic speciation, we demonstrate that IL-10 gene knockout leads to a significant taxonomic change of the gut microbiome, which in turn substantially affects arsenic metabolism.