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HERO ID
2677590
Reference Type
Journal Article
Subtype
Review
Title
Chlorinated Persistent Organic Pollutants, Obesity, and Type 2 Diabetes
Author(s)
Lee, D; Porta, M; Jacobs, DR, Jr; Vandenberg, LN
Year
2014
Is Peer Reviewed?
1
Journal
Endocrine Reviews
ISSN:
0163-769X
EISSN:
1945-7189
Volume
35
Issue
4
Page Numbers
557-601
Language
English
PMID
24483949
DOI
10.1210/er.2013-1084
Web of Science Id
WOS:000342346100001
Abstract
Persistent organic pollutants (POPs) are lipophilic compounds that travel with lipids and accumulate mainly in adipose tissue. Recent human evidence links low-dose POPs to an increased risk of type 2 diabetes (T2D). Because humans are contaminated by POP mixtures and POPs possibly have nonmonotonic dose-response relations with T2D, critical methodological issues arise in evaluating human findings. This review summarizes epidemiological results on chlorinated POPs and T2D, and relevant experimental evidence. It also discusses how features of POPs can affect inferences in humans. The evidence as a whole suggests that, rather than a few individual POPs, background exposure to POP mixtures-including organochlorine pesticides and polychlorinated biphenyls-can increase T2D risk in humans. Inconsistent statistical significance for individual POPs may arise due to distributional differences in POP mixtures among populations. Differences in the observed shape of the dose-response curves among human studies may reflect an inverted U-shaped association secondary to mitochondrial dysfunction or endocrine disruption. Finally, we examine the relationship between POPs and obesity. There is evidence in animal studies that low-dose POP mixtures are obesogenic. However, relationships between POPs and obesity in humans have been inconsistent. Adipose tissue plays a dual role of promoting T2D and providing a relatively safe place to store POPs. Large prospective studies with serial measurements of a broad range of POPs, adiposity, and clinically relevant biomarkers are needed to disentangle the interrelationships among POPs, obesity, and the development of T2D. Also needed are laboratory experiments that more closely mimic real-world POP doses, mixtures, and exposure duration in humans.
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IRIS
•
PCBs
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