Screening catalysts for the catalytic exchange of hydrogen by tritium using magnetic labeling | Health & Environmental Research Online (HERO)

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HERO ID

2858269

Reference Type

Journal Article

Title

Screening catalysts for the catalytic exchange of hydrogen by tritium using magnetic labeling

Author(s)

Niessen, HG; Ulrich, C; Bargon, J

Year

2000

Is Peer Reviewed?

Yes

Journal

Journal of Labelled Compounds and Radiopharmaceuticals
ISSN: 0362-4803
EISSN: 1099-1344

Volume

Issue

Page Numbers

711-720

Language

English

DOI

10.1002/1099-1344(200006)43:7<711::AID-JLCR356>3.0.CO;2-Q

Web of Science Id

WOS:000087346800009

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034068303&doi=10.1002%2f1099-1344%28200006%2943%3a7%3c711%3a%3aAID-JLCR356%3e3.0.CO%3b2-Q&partnerID=40&md5=2b2c214b1063513ca582c4fb15e07446
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Abstract

Isotope labeling is an important method to evaluate drugs and compounds for agricultural use. Therefore, a fast and convenient method to selectively exchange hydrogen against non-radioactive deuterium or radioactive tritium in the final product is desirable. PHIP-NMR investigations of the influence of CO on the selective exchange of the geminal protons in styrene show that CO increases the efficiency of the selective exchange non-linearly and suppresses the hydrogenation of styrene to ethylbenzene.

Keywords

catalysis; NMR; hydrogenation; exchange reactions; magnetic labeling