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3036106 
Technical Report 
NTP 
Eleventh report on carcinogens: Methylene chloride 
National Toxicology Program :: NTP 
2004 
National Toxicology Program 
Research Triangle Park, NC 
Report on carcinogens: Eleventh edition 
III136-III137 
2 
English 
is a chapter of 093207 11th Report on carcinogens
Dichloromethane (methylene chloride) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity in experimental animals (NTP 1986). When administered by inhalation, the compound is carcinogenic in mice and female rats. It caused increased incidences of alveolar/bronchiolar neoplasms and hepatocellular neoplasms in mice of both sexes. Dichloromethane inhalation also increased the incidences of fibroadenoma of the mammary gland in female rats. There is some evidence of the carcinogenicity of dichloromethane in male rats, as shown by an increased incidence of fibroadenoma of the mammary gland (NTP 1986, IARC 1987). No adequate human studies of the relationship between exposure to dichloromethane and human cancer were found (IARC 1979, 1982, 1999). 
11th