US EPA

3981919 

Journal Article 

The effect of perfluorooctanoic acid on the planarian Dugesia japonica 

Yuan, Z; Zhang, J; Zhang, Y; Zhen, Hui; Sun, Y 

2015 

1 

Polish Journal of Environmental Studies
ISSN: 1230-1485
EISSN: 2083-5906 

24 

2 

801-807 

English 

10.15244/pjoes/32098 

WOS:000352746500044 

http://dx.doi.org/10.15244/pjoes/32098
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Perfluorooctanoic acid (PFOA) has been found to distribute and accumulate widely in the environment. In this study, the acute toxicity, behavioral activity, regeneration, antioxidant enzyme activities, and cell apoptosis effects of PFOA on planarian Dugesia japonica have been investigated. The results show that the mortality is directly proportional to the PFOA concentration, and planarian locomotor velocity (pLMV) is significantly reduced with increasing both the exposure time and PFOA concentration. The recovery of the motility for planarians pre-treated with PFOA is found to be time- and dose-dependent, and all planarians recover their motility completely after 72 hr. The appearance of auricles in regenerating animals is more easily affected by PFOA exposure in comparison to the appearance of eyespot. The SOD activities and CAT activities are changed in the PFOA-exposed planarians. Increasing PFOA exposure time or concentration can cause an obvious increase of apoptosis in the brain, eye, and parenchyma region. The results suggest that PFOA is much more toxic for inducing oxidative stress, cell apoptosis, and development toxicity in planarians. 

planarian; perfluorooctanoic acid; toxicity; regeneration; apoptosis