Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has multiple attached files:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
5024245
Reference Type
Journal Article
Title
Validation of quantitative measurements and semi-quantitative estimates of emerging perfluoroethercarboxylic acids (PFECAs) and hexfluoroprolyene oxide acids (HFPOAs)
Author(s)
McCord, J; Newton, S; Strynar, M
Year
2018
Is Peer Reviewed?
Yes
Journal
Journal of Chromatography A
ISSN:
0021-9673
EISSN:
1873-3778
Volume
1551
Page Numbers
52-58
Language
English
PMID
29628221
DOI
10.1016/j.chroma.2018.03.047
Web of Science Id
WOS:000432499600006
Relationship(s)
is supplemented by
11374638
: Supporting information
Abstract
Legacy perfluorinated compounds exhibit significant environmental persistence and bioaccumulation potential, which has spawned an ongoing effort to introduce replacement compounds with reduced toxicological risk profiles. Many of these emerging chemical species lack validated quantitative methods, and, frequently, appropriate analytical standards for accurate monitoring and identification. To fill this knowledge gap, a general method for the quantitative determination of perfluoroether carboxylic acids (PFECAs) by LC-MS/MS was single-lab validated on spike-recovery samples in surface, drinking, and wastewater for a variety of perfluorinated ether standards. Relative error measurements for spike-recovery samples in each matrix ranged from 0.36% to 25.9%, with an average error of 10% overall. Coefficient of variation (CV) for each compound ranged from 10 to 28% with an average of 17%. The quantitative methodology was applied during repeated weekly monitoring of the Cape Fear River during remediation of PFECA hexafluoropropyloxide dimer-acid (HFPO-DA), known by the brand name "GenX." Semi-quantitative concentration estimates for emerging PFECA compounds lacking analytical standards was also carried out using surrogate calibration curves and mass labeled HFPO-DA as an internal standard. Estimates of the emerging compounds were possible using matched standards, but application of the estimation methodology to compounds with known concentration revealed that such estimates may possess up to an order of magnitude, or more, in uncertainty due to the difficulty of matching with an appropriate standard. Nevertheless, the estimation biases are primarily systematic (extraction efficiency and instrument response) rather than stochastic, enabling the collection of time-course data; both HFPO-DA and the emerging compounds were reduced in surface water and drinking water concentration of several orders of magnitude after removal of the source waste stream.
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
Expanded PFAS SEM (formerly PFAS 430)
Ammonium 4,8-dioxa-3H-perfluorononanoate
•
GenX Chemicals (CASRN 13252-13-6 and CASRN 62037-80-3)
LitSearch - GenX: July 2017 - Feb 2019
PubMed
WoS
LitSearch GenX Ammonium Salt: Feb 2018 - Feb 2019
PubMed
WoS
•
PFAS 150
Literature Search Update December 2020
PubMed
Literature Search August 2019
PubMed
Not prioritized for screening
Ammonium perfluoro-2-methyl-3-oxahexanoate
Perfluorinated compounds
Perfluoro-2-methyl-3-oxahexanoic acid
•
PFNA
Literature Search
Toxline
PFNA May 2019 Update
Toxnet
Title and Abstract Screening
Tagged as Supplemental
Environmental occurance
Manufacture/use
Laboratory Method
Environmental fate
Other PFAS
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity