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Citation
Tags
HERO ID
5082178
Reference Type
Journal Article
Title
Destabilizing effect of perfluorodecanoic acid on simple membrane models
Author(s)
Viada, B; Cámara, CI; Yudi, LM
Year
2019
Is Peer Reviewed?
1
Journal
Soft Matter
ISSN:
1744-683X
Publisher
ROYAL SOC CHEMISTRY
Location
CAMBRIDGE
Volume
15
Issue
11
Page Numbers
2447-2462
Language
English
PMID
30801603
DOI
10.1039/c8sm02301h
Web of Science Id
WOS:000462665500012
URL
http://xlink.rsc.org/?DOI=C8SM02301H
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Abstract
Perfluoroalkyl acids (PFA) are amphiphilic surfactants widely used in industry with several commercial applications. An important feature of these compounds is their non-biodegradability and their tendency to bio-accumulate in the environment, which has led to these compounds being considered among the most persistent pollutants worldwide. Many studies have provided evidence of their toxic effect on humans and wildlife. For this reason, more and more efforts have been made to better understand the effect of these compounds on living organisms. The aim of the present study is to understand how the electrostatic interactions and film compactness of biological membrane models modulate their interaction with PFA, more specifically with perfluorodecanoic acid (PFD). Langmuir isotherms and Brewster angle microscopy (BAM) are used to evaluate the effect of PFD on lipid membrane models (air/water monolayers and vesicles), analyzing the behavior of PFD : lipid mixtures. The lipids used in this study are distearoyl phosphatidic acid (DSPA), dilauroyl phosphatidic acid (DLPA) and distearoyl phosphatidylethanolamine (DSPE). PFD induces an increase in the mean molecular area per lipid in monolayers, mainly at lower surface pressures. BAM images demonstrate that PFD mixes with DLPA, inducing a decrease in gray level, while it forms a non-miscible mixture with DSPA, segregating PFD domains. Insertion studies of PFD within monolayers and dynamic light scattering experiments demonstrate that PFD can penetrate into monolayers and bilayers above 30 mN m-1, which is the lateral pressure value accepted for a cellular bilayer.
Keywords
Physics; Light scattering; Biodegradation; Phosphatidylethanolamine; Pollutants; Brewster angle; Electrostatic properties; Biodegradability; Perfluorodecanoic acid; Perfluoro compounds; Domains; Perfluoroalkyls; Phosphatidic acid; Wildlife; Surfactants; Monolayers; Microscopy; Photon correlation spectroscopy; Lateral pressure
Tags
PFAS
•
Additional PFAS (formerly XAgency)
Literature Search November 2019
Other Sources
TEDX
Screened Studies
Excluded
Exclude (TIAB)
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
Web of Science
Other Sources
PFAS TOX Database
Screened Studies
Excluded
Exclude (TIAB)
Not prioritized for screening
Perfluorooctane
•
PFAS 150
Literature Search Update December 2020
WOS
Literature Search August 2019
PubMed
Web of Science
Other sources
PFAS TOX Database
Not prioritized for screening
Perfluorodecanoic acid
Perfluorooctane
Perfluorooctanesulfonic acid
•
PFAS Universe
Data Source
Web of Science
Pubmed
Perfluorodecanoic acid
Perfluorooctane
Perfluorooctanesulfonate
•
PFDA
Literature Search
Pubmed
WOS
Other
Published PFAS SEMs
Literature Search Update 5/2019
PubMed
Literature Search Update 4/2021
WoS
Scopus: April 2021
June 2022 Pelch Database
Literature Searches (through April 2023 update and post-public comment/peer review)
Title & Abstract Screening
Tagged as Supplemental
In vitro and in silico models
•
PFNA
OW - HHRAB
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search Update (2013-2019)
WOS
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