Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
5083694
Reference Type
Journal Article
Title
Efficiency of maternal-fetal transfer of perfluoroalkyl and polyfluoroalkyl substances
Author(s)
Wang, Y; Han, W; Wang, C; Zhou, Y; Shi, R; Bonefeld-Jørgensen, EC; Yao, Q; Yuan, T; Gao, Y; Zhang, J; Tian, Y
Year
2019
Is Peer Reviewed?
Yes
Journal
Environmental Science and Pollution Research
ISSN:
0944-1344
EISSN:
1614-7499
Publisher
SPRINGER HEIDELBERG
Location
HEIDELBERG
Volume
26
Issue
3
Page Numbers
2691-2698
Language
English
PMID
30484044
DOI
10.1007/s11356-018-3686-3
Web of Science Id
WOS:000456198400055
URL
https://www.proquest.com/docview/2139156753?accountid=171501&bdid=35863&_bd=3Zlg5UeGdC6UcvKwp0KDhpTqW0E%3D
Exit
Abstract
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) can be transferred from a mother to her fetus during pregnancy and adversely affect fetal development. However, the efficiency and influencing factors of PFASs maternal-fetal transfer remain unclear. We measured the levels of six perfluoroalkylcarboxylates, three perfluoroalkylsulfonates, and one sulfonamide in 369 pairs of maternal and umbilical cord serum and examined the transplacental transfer efficiency (TTE) of PFASs by the functional group and carbon chain length in a prospective birth cohort in Shandong, China. All ten PFASs were detected in both maternal and umbilical cord serum in nearly all samples. Maternal and cord levels were closely correlated (the correlation coefficient [r] ranging from 0.485 to 0.908) in most PFASs except perfluorobutane sulfonic acid (PFBS) (r = 0.159). TTE was significantly affected by the functional group and carbon chain length. Compared to perfluoroalkylcarboxylates, perfluoroalkylsulfonates had a lower ratio of maternal to fetal transfer. A U-shaped relationship between carbon chain length and TTE was observed for perfluoroalkylcarboxylates while a monotonic descending trend was identified between TTE and the increasing carbon chain length for perfluoroalkylsulfonates. PFASs can readily pass through the placenta. The functional group and carbon chain length are important determinants for the TTE of PFASs.
Keywords
Perfluoroalkylcarboxylates; Perfluoroalkylsulfonates; Transplacental transfer efficiency; China
Tags
PFAS
•
Additional PFAS (formerly XAgency)
Literature Search November 2019
Other Sources
Reference list review of included studies
Screened Studies
Supplemental
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
Web of Science
Screened Studies
Supplemental
Perfluorooctane
•
PFAS 150
Literature Search Update December 2020
PubMed
WOS
Literature Search August 2019
PubMed
Web of Science
ToxNet
Not prioritized for screening
Perfluorinated compounds
Perfluorobutanesulfonic acid
Perfluorobutanesulfonyl fluoride
Perfluorooctane
Perfluorooctanesulfonic acid
•
PFBS
Search
PubMed
WOS
Lit Search Update: May 2019
PubMed
WOS
Scopus: April 2021
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search Update (2013-2019)
WOS
•
PFOA and PFOS OW MCLG Approaches
Cited in White Papers
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity