US EPA

63444 

Technical Report 

IARC Monograph 

Di(2-ethylhexyl) phthalate 

International Agency for Research on Cancer :: IARC 

1982 

International Agency for Research on Cancer 

Lyon, France 

Some industrial chemicals and dyestuffs 

29 

269-294 

English 

6751991 

http://monographs.iarc.fr/ENG/Monographs/vol77/mono77-7.pdf
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is part of a larger document 027010 IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans: Some industrial chemicals and dyestuffs

Di(2-ethylhexyl) phthalate was tested in mice and rats by oral administration: It significantly increased the incidence of benign and malignant liver-cell tumours in animals of both species, and a dose-response relationship was observed. Di(2-ethylhexyl) phthalate can cause testicular damage in rats. There is evidence that this compound and its metabolite, mono(2-ethylhexyl) phthalate, are teratogenic and embryolethal to rodents. Di(2-ethylhexyl) phthalate was not mutagenic to Salmonella typhimurium. However, it caused dominant lethal mutations in mice after systemic but not oral administration. Occupational exposure to di(2-ethylhexyl) phthalate probably occurs during its manufacture, its use as a plasticizer, its use in dielectric fluids for electrical capacitors and in the further processing or use of plasticized products containing it. Its reported widespread occurrence in ambient air, in drinking, river and ocean waters, in industrial effluents, in foods and in blood stored in plasticized bags indicates environmental exposure and exposure of the general human population. No data were available to assess the mutagenicity or teratogenicity of this compound to man. No adequate epidemiological study was available to the Working Group. There is sufficient evidence for the carcinogenicity of di(2-ethylhexyl) phthalate in mice and rats. No adequate epidemiological study was available. 

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 

9789283212294