US EPA

657868 

Journal Article 

Behavior of mice after pre- and postnatal exposure to Arochlor 1254 

Storm, JE; Hart, JL; Smith, RF 

1981 

1 

Neurobehavioral Toxicology and Teratology
ISSN: 0275-1380 

HEEP/82/07578 

3 

1 

5-9 

WOS:A1981LN38300002 

http://://WOS:A1981LN38300002
Exit
 

is related to other part(s) 5024163 [Email to Dr. Laura Carlson regarding study evaluation details on Storm et al. 1981]

Female mice were mice were maintained on a diet containing 0, 11 or 82 ppm of Arochlor 1254, a mixture of polychlorinated biphenyls (PCBs), beginning three days prior to mating and continuing until their litters were weaned at 21 days of age. The offspring were then maintained on the same diet to which their mothers had been exposed. PCB exposure had no effect on the ability of mice to learn an avoidance response. However, measures of response latency indicated a significant interaction between diet and latency to make an avoidance response, with PCB exposed mice showing increased latency early in training. Measures of activity in the open field indicated a significant interaction between diet and activity measured per five minute period, with decreases in activity over time occurring more slowly in PCB exposed mice. 

avoidance learning; behavior; intrauterine exposure