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HERO ID
672940
Reference Type
Journal Article
Subtype
Review
Title
Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association
Author(s)
Brook, RD; Rajagopalan, S; Pope CA III; Brook, , JR; Bhatnagar, A; Diez-Roux, AV; Holguin, F; Hong, Y; Luepker, RV; Mittleman, MA; Peters, A; Siscovick, D; Smith, SC, Jr; Whitsel, L; Kaufman, JD
Year
2010
Is Peer Reviewed?
Yes
Journal
Circulation
ISSN:
0009-7322
EISSN:
1524-4539
Volume
121
Issue
21
Page Numbers
2331-2378
Language
English
PMID
20458016
DOI
10.1161/CIR.0b013e3181dbece1
Web of Science Id
WOS:000278213100012
URL
http://www.ncbi.nlm.nih.gov/pubmed/20458016
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Abstract
In 2004, the first American Heart Association scientific statement on "Air Pollution and Cardiovascular Disease" concluded that exposure to particulate matter (PM) air pollution contributes to cardiovascular morbidity and mortality. In the interim, numerous studies have expanded our understanding of this association and further elucidated the physiological and molecular mechanisms involved. The main objective of this updated American Heart Association scientific statement is to provide a comprehensive review of the new evidence linking PM exposure with cardiovascular disease, with a specific focus on highlighting the clinical implications for researchers and healthcare providers. The writing group also sought to provide expert consensus opinions on many aspects of the current state of science and updated suggestions for areas of future research. On the basis of the findings of this review, several new conclusions were reached, including the following: Exposure to PM <2.5 microm in diameter (PM(2.5)) over a few hours to weeks can trigger cardiovascular disease-related mortality and nonfatal events; longer-term exposure (eg, a few years) increases the risk for cardiovascular mortality to an even greater extent than exposures over a few days and reduces life expectancy within more highly exposed segments of the population by several months to a few years; reductions in PM levels are associated with decreases in cardiovascular mortality within a time frame as short as a few years; and many credible pathological mechanisms have been elucidated that lend biological plausibility to these findings. It is the opinion of the writing group that the overall evidence is consistent with a causal relationship between PM(2.5) exposure and cardiovascular morbidity and mortality. This body of evidence has grown and been strengthened substantially since the first American Heart Association scientific statement was published. Finally, PM(2.5) exposure is deemed a modifiable factor that contributes to cardiovascular morbidity and mortality.
Keywords
AHA Scientific Statements; atherosclerosis; epidemiology; prevention; air pollution; public policy
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ISA-Lead (2013 Final Project Page)
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ISA-NOx (2016)
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ISA-PM (2019)
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Atmospheric Science
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LitSearch-NOx (2024)
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MSA-Multipollutant Exposure Metric Review
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