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675105 
Journal Article 
Abstract 
Decreased anogenital distance and increased incidence of undescended testes in male offspring of rats given monobenzyl phthalate, a major metabolite of butyl benzyl phthalate, during late pregnancy 
Ema, M; Miyawaki, E; Hirose, A; Kamata, E 
2003 
Yes 
Congenital Anomalies
ISSN: 0914-3505
EISSN: 1741-4520 
DART/TER/4000402 
43 
3 
244-245 
English 
is related to other part(s) 675096 Decreased anogenital distance (AGD) and undescended testes in fetuses of rats given monobenzyl phthalate (MBeP) during pregnancy
is part of a larger document 3230432 The Japanese teratology society 43rd annual meeting abstracts
We previously showed that maternal exposure to butyl benzyl phthalate (BBP) on days 15-17 of pregnancy caused decreased anogenital distance (AGD) and an increased incidence of male fetuses with undescended tested in rats (Reprod Toxicol, 16: 71-76, 2002). In this study, we determined the adverse effects of monobenzyl phthalate (MBeP), a major metabolite of BBP, on the development of the reproductive system and assessed the role of MBeP in the antiandrogenic effects of BBP. Pregnant rats were given MBeP by gavage at 167, 250, or 375 mg/kg on days 15-17 of pregnancy. Fetuses were examined on day 21 of pregnancy. Maternal body weight gain and food consumption were significantly decreased at 167 mg/kg and higher. The fetal weights were significantly lowered at 375 mg/kg. A significant decrease in the AGD and ratio of AGD to the cube root of body weight was noted in male fetuses at 250 mg/kg and higher. A significant increase in the incidence of fetuses with undescended testes was found at 250 mg/kg and higher. The AGD and ratio of AGD to the cube root of body weight of female fetuses in the MBeP-treated groups were comparable to those in the control group. The present data indicate that MBeP produces adverse effects on the development of the reproductive system in male offspring and suggest that MBeP may be responsible for the induction of the antiandrogenic effects of BBP. 
Pregnancy; Rats; Animals; Male; Female; Phthalic Acids/METABOLISM; Phthalic Acids/TOXICITY; Prenatal Exposure Delayed Effects; Abnormalities, Drug-Induced/ETIOLOGY; Anus/ABNORMALITIES; Genitalia, Male/ABNORMALITIES; Cryptorchidism/CHEMICALLY INDUCED; Dose-Response Relationship, Drug; NO CAS RN; 85-68-7; 2528-16-7 
Annual Meeting of the Teratology Society