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681622 
Journal Article 
Evaluation of di-(2-ethylhexyl)phthalate and its major metabolites in the Ames test and L5178Y mouse lymphoma mutagenicity assay 
Kirby, PE; Pizzarello, RF; Lawlor, TE; Haworth, SR; Hodgson, JR 
1983 
Yes 
Environmental Mutagenesis
ISSN: 0192-2521
EISSN: 1930-238X 
5 
5 
657-663 
English 
6352251 
WOS:A1983RL76200002 
has other version or edition 790899 Evaluation of di-(2-ethylhexyl)phthalate and its major metabolites in the ames test and l5178y mouse lymphoma mutagenicity assay
Di-(2-ethylhexyl)phthalate (DEHP) and its two major metabolites, mono-(2-ethylhexyl)phthalate (MEHP) and 2-ethylhexanol (EH), were tested for genetic activity in both the Salmonella/mammalian microsome mutagenicity (Ames) assay and the L5178Y TK+/- mouse lymphoma cell mutagenicity assay. All chemicals were tested in both the presence and absence of Aroclor-induced liver microsomes prepared from male Sprague-Dawley rats. Dose levels for both assays were selected from preliminary toxicity studies for each chemical. Neither DEHP, MEHP, nor EH exhibited any significant mutagenic activity in strains TA-98, TA-100, TA-1535, TA-1537, and TA-1538 in the Ames test or when tested in the L5178Y TK+/- mouse lymphoma cell mutagenicity assay 
analogs & derivatives; Animals; Biotransformation; Diethylhexyl Phthalate; drug effects; genetics; Hexanols; Leukemia L5178; Leukemia,Experimental; Liver; Lymphoma; Male; metabolism; Mice; Microsomes; Microsomes,Liver; Mutagenicity Tests; Mutagens; Mutation; Phthalic Acids; Plasticizers; Rats; Salmonella typhimurium; Structure-Activity Relationship; toxicity 
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