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HERO ID
10284765
Reference Type
Journal Article
Subtype
Supplemental Data
Title
Supporting information: Poly- and perfluoroalkyl substance concentrations in human breast milk and their associations with postnatal infant growth
Author(s)
Jin, H; Mao, L; Xie, J; Zhao, M; Bai, X; Wen, J; Shen, T; Wu, P
Year
2020
Is Peer Reviewed?
1
Journal
Science of the Total Environment
ISSN:
0048-9697
EISSN:
1879-1026
Volume
713
Language
English
URL
http://www.sciencedirect.com/science/article/pii/S0048969719364137
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Relationship(s)
is a supplement to
6316202
Poly- and perfluoroalkyl substance concentrations in human breast milk and their associations with postnatal infant growth
Abstract
Perfluoroalkyl carboxylates (PFCAs) and perfluoroalkyl sulfonates are widespread in human breast milk. However, the occurrence of chlorinated polyfluorinated ether sulfonates (Cl-PFESAs) and fluorotelomer alcohols (FTOHs) in breast milk and their effects on postnatal growth of infants through breast milk consumption are still not well known. This study characterized the occurrence of 16 poly- and perfluoroalkyl substances (PFASs) in breast milk from 174 women in Hangzhou, China and investigated the association between lactation exposure to these PFASs through breast milk consumption and the postnatal growth of infants. Our results showed that perfluorooctanoate (mean 87 pg/mL) was the predominant PFAS in breast milk, followed by perfluorohexanoate (41 pg/mL), 6:2 Cl-PFESA (28 pg/mL), and perfluorooctane sulfonate (25 pg/mL). The occurrence and levels of Cl-PFESAs in Chinese breast milk were firstly reported in the current study. The 8:2 and 10:2 FTOH were detected in half of breast milk samples, with the mean concentration of 9.0 pg/mL and 10 pg/mL, respectively. Breast milk concentrations of C8-C10 PFCAs and 6:2 Cl-PFESA were negatively correlated with infant's length gain rate. Exposed to higher levels of 8:2 FTOH were correlated with decreased infant's weight gain rate. Daily intakes of PFASs via the consumption of breast milk were calculated for infants. Overall, this study firstly demonstrated that lactation exposure to C8-C10 PFCAs, 8:2 FTOH, and 6:2 Cl-PFESA through breast milk consumption may affect the postnatal growth of infants.
Keywords
Postnatal infant growth; Human breast milk; Chlorinated perfluoroalkyl ether sulfonic acid; Perfluorooctane sulfonate
Tags
•
PFAS 150
Literature Search Update December 2020
PubMed
Literature Search August 2019
PubMed
Other sources
Reference list review of included studies
Screened Studies
Included
Include (TIAB)
Include (Full Text)
6:2 Fluorotelomer alcohol
Perfluorooctane
(Perfluorooctyl)ethanol
•
PFHxA
LitSearch Update: May 2019 - May 2020
PubMed
WoS
Scopus: April 2021
HAWC
•
PFHxS
•
PFOA (335-67-1) and PFOS (1763-23-1)
LitSearch: Feb 2019 - May 2020
PubMed
WoS
Literature Search Update (Apr 2019 - Sep 2020)
PubMed
WOS
•
PFOA and PFOS OW MCLG Approaches
Cited in White Papers
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