US EPA

1341269 

Journal Article 

Development and evaluation of propranolol hydrochloride transdermal patches by using hydrophilic and hydrophobic polymer 

Dey, BK; Nath, LK; Mohanti, B; Bhowmik, BB 

2007 

1 

Indian Journal of Pharmaceutical Education & Research
ISSN: 0019-5464 

41 

4 

388-393 

WOS:000259222600017 

Propranolol hydrochloride is a non-selective beta adrenergic blocking agent and clinically used in angina pectoris, cardiac arrhythmia and in
hypertension. It inhibits response to adrenergic stimuli by competitively blocking beta-
adrenergic receptors in the myocardium, bronchial and vascular smooth muscles. The drug has been
reported for potential administration through transdermal route. Present investigation was
carried out to study the effect of different proportions of ethyl cellulose and polyvinyl
pyrrolidone, a hydrophobic and a hydrophilic polymer respectively, on the permeation profile of
the drug across the rat abdomen for the development of a reproducible transdermal therapeutic
system of propranolol hydrochloride. Transdermal films were prepared using ten different
combinations of the two polymers by solvent evaporation technique. Polyvinyl alcohol was used to
prepare the backing membrane and dibutyl phthalate as plasticizer. Several physicochemical
parameters like moisture content, moisture loss, thickness, film folding endurance, tensile
strength and film elongation were studied. For all the formulations, skin permeation of the drug
through rat abdomen was studied using Keshary-Chien diffusion cell. Formulations with highest
proportion of polyvinyl pyrrolidone shows faster release over a day's span whereas increasing
proportion of ethyl cellulose produces a prolonged regimen of sustained drug delivery through
transdermal route for a period of more than a day. The present study has demonstrated the
potential of the fabricated matrix films for prolonged release of propranolol hydrochloride. 

propranolol hydrochloride; transdermal therapeutic system (TTS); ethyl cellulose (EC); polyvinyl pyrrolidone (PVP)