US EPA

1341633 

Journal Article 

Citalopram Analysis in Formulation and Urine by a Novel Citalopram Potentiometric Membrane Sensor 

Faridbod, F; Ganjali, MR; Dinarvand, R; Riahi, S; Norouzi, P; Olia, MBA 

2009 

Yes 

Journal of Food and Drug Analysis
ISSN: 1021-9498 

17 

4 

264-273 

English 

WOS:000269845100004 

https://search.proquest.com/docview/1282141598?accountid=171501
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Citalopram is an antidepressant drug used to treat
depression associated with mood disorders. This research introduces the design of an ion-pair
based polyvinylchloride (PVC) membrane sensor for the citalopram determination based on
theoretical investigations. For the membrane preparation, citalopram-tetraphenyl borate ion-pair
was employed as an electroactive material in the PVC membrane. In parallel, several plasticizers
were studied, i.e. dibutyl phthalate (DBP), acetophenon (AP), nitrobenzene (NB) and
nitrophenyloctyl ether (o-NPOE). After a series of experiments, the best electrode performance
was accomplished with a membrane composition of 30% PVC, 66% DBP, and 4% ion-pair. This electrode
illustrated a fast (similar to 5 s), stable and Nernstian response (58.6 +/- 0.3 mV/decade)
across a relatively wide citalopram concentration range 1x10(-5) to 1x10(-2) M and in the pH
range of 3.0-5.5. Validation of the method showed suitability of the sensors for the quality
control analysis of citalopram hydrobromide in pharmaceutical formulation and urine. The proposed
method was simple, accurate and precise and can be used as a detector for HPLC. 

potentiometric sensor; PVC membrane; ion-pair; citalopram; Density Functional Theory; chemometrics