US EPA

1479834 

Journal Article 

Acute Toxicitiy, Inhalation toxicity and skin irritation of Cyclododecane (CD, Tricyclododecane (TCD), Naphthaline (NP) and Para-Dichlorobenzene (PZ) 

I, Daisuke; Sasaki, T; Ito, R 

1973 

0 

Toho Igakkai Zasshi / Journal of the Medical Society of Toho University
ISSN: 0040-8670 

20 

56 

772-775 

English 

The toxicity of cyclododecane (294622) (CD), tricyclododecane (53126651) (TCD), naphthaline (91203) (NP) and perazol (103128) (paradichlorobenzene) (PZ) was investigated in mice and rabbits. Median subcutaneous lethal doses (LD 50) were determined in mice following acute toxicity tests. Inhalation and dermal toxicity in mice and rabbits, respectively, also were evaluated. LD50s for CD and TCD were greater than 10,000 milligrams per kilogram (mg/kg) LD50s for NP and PZ were 969 and 5,145mg/kg, respectively. NP and PZ were nerve toxins, and respiratory failure was the cause of death. Inhalation toxicity tests after one 8 hour exposure to CD, TCD, PZ, or NP revealed increased breathing rate and inertia in the mice, but no mortality occurred. Three test animals died after repeated exposures to TCD and CD continuously for 2 weeks. Blood test after day 14 showed a blood density of 6.5 parts per million (ppm) for PZ and 1ppm for TCD; mice exposed to PZ had slight liver damage. The repeated application of CD to rabbit skin caused only small red spots in some areas. The authors conclude that the toxicities of CD and TCD are lower than the toxicities of NP and PZ. (Japanese). 

DCN-182726; TRANS; Toxic effects; Industrial chemicals; Laboratory animals; Lethal dose; Lung disorders; Skin disorders; Analytical methods; Hematology; Liver disorders