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HERO ID
1597680
Reference Type
Journal Article
Title
Urinary concentrations of bisphenol A in an urban minority birth cohort in New York City, prenatal through age 7 years
Author(s)
Hoepner, LA; Whyatt, RM; Just, AC; Calafat, AM; Perera, FP; Rundle, AG
Year
2013
Is Peer Reviewed?
Yes
Journal
Environmental Research
ISSN:
0013-9351
EISSN:
1096-0953
Volume
122
Page Numbers
38-44
Language
English
PMID
23312110
DOI
10.1016/j.envres.2012.12.003
Web of Science Id
WOS:000317253500006
Abstract
BACKGROUND:
Despite growing concern over potential health effects associated with exposures to the endocrine disruptor, bisphenol A (BPA), insufficient information is available on determinants of BPA concentrations among minority populations in the US.
OBJECTIVES:
To describe concentrations and predictors of BPA in an inner-city longitudinal birth cohort.
METHODS:
We analyzed spot urines for total BPA collected during pregnancy and child ages 3, 5, and 7 years from African Americans and Dominicans (n=568) enrolled in the Columbia Center for Children's Environmental Health birth cohort and residing in Northern Manhattan and the South Bronx. Adjusting for specific gravity, generalized estimating equations were used to compare BPA concentrations across paired samples and linear regression analyses were used to determine relationships between BPA, season of sample collection, socio-demographic variables and urinary concentrations of phthalate metabolites.
RESULTS:
BPA was detected in ≥ 94% of samples. Prenatal concentrations were significantly lower than postnatal concentrations. Geometric means were higher among African Americans compared to Dominicans in prenatal (p=0.008), 5 year (p<0.001) and 7 year (p=0.017) samples. Geometric means at 5 and 7 years were higher (p=0.021, p=0.041 respectively) for children of mothers never married compared to mothers ever married at enrollment. BPA concentrations were correlated with phthalate metabolite concentrations at prenatal, 3, 5 and 7 years (p-values <0.05). Postnatal BPA concentrations were higher in samples collected during the summer.
CONCLUSIONS:
This study shows widespread BPA exposure in an inner-city minority population. BPA concentration variations were associated with socio-demographic characteristics and other xenobiotics.
Keywords
Bisphenol A; Urine; Child; Prenatal; Minority
Tags
IRIS
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Toxnet
Excluded
Source – no date limit through June 2013 (Private)
Pubmed
WOS
ToxNet
Source - Dec 2013 Update (Private)
WOS
ToxNet
Source - Jun 2014 Update (Private)
WOS
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