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1936033 
Journal Article 
Novel identification of lipid-soluble arsenic compounds using chemical derivatisations in conjunction with RP-HPLC-ICPMS/ESMS 
Amayo, KO; Raab, A; Krupp, EM; Gunnlaugsdottir, H; Feldmann, J 
In Press 
Yes 
Analytical Chemistry
ISSN: 0003-2700
EISSN: 1520-6882 
85 
19 
9321–9327 
English 
The identification of molecular structures of arsenolipid is pivotal for its toxicological assessment and in understanding the arsenic cycling in the environment. However, analysis of these compounds in lipid matrix is an ongoing challenge. So far only few arsenolipids have been reported, such as arsenic fatty acids (AsFAs) and arsenic hydrocarbons (AsHCs). By means of RP-HPLC-ICPMS/ESMS, we investigated Capelin oil (Mallotus villosus) for possible new species of arsenolipid. Twelve arsenolipids were identified in the fish oil including three AsFAs and seven AsHCs. Among the AsHCs, four of them identified with protonotated molecular masses 305, 331, 347 and 359 have not been reported before. In addition, the compounds with molecular formulae C20H44AsO+ and C24H44AsO+ found in low concentrations showed chromatographic properties and MS data consistent with cationic trimethylarsenio fatty alcohols. Derivatisation by acetylation and thiolation coupled with accurate mass spectrometry was successfully used to establish the occurrence of this new class of arsenolipids as cationic trimethylarsenio fatty alcohols (TMAsFOH). 
IRIS
• Arsenic Hazard ID
          PubMed
          Considered New
          PubMed
          Considered New
          PubMed
          Considered New
          ToxNet
          Considered New
          ToxNet
          Excluded
               Toxnet Duplicates
     2. Lit Search Updates through Oct 2015
          PubMed
          ToxNet
          Considered
     7. Other Studies through Oct 2015
          Other
• Arsenic (Inorganic)
     1. Literature
          Lit search updates through Oct 2015
     3. Hazard ID Screening
          Other potentially supporting studies