US EPA

202611 

Journal Article 

A novel route of excretion of 2, 4, 3', 4'-tetrachlorobiphenyl in rats 

Yoshimura, H; Yamamoto, H-A 

1975 

Yes 

Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 

NIOSH/00080462 

13 

6 

681-688 

English 

806316 

10.1007/BF01721936 

WOS:A1975AG90100008 

Polychlorinated biphenyls (PCBs), one of the environmental pollutants, in parallel with other organic chlorocompounds (BHC, DDT, dieldrin and others) have been accumulated in human tissues through food chains, because of their high degree of biochemical stability and lipid solubility, and found to be hardly eliminated from human tissues (BIROS et al. 1970). However, in our previous study on the elimination of PCBs preparation, Kanechlor-400 (KC-400), with about 48 % chlorine content, it was found that even the components with high chlorine content (more than tetrachloro-derivatives) were eliminated very gradually from mice tissues (YOSHIMURA and 6SHIMA 1971). WILLIAMS et al. (1965) found that dieldrin injected intravenously into the bile duct cannulated rats was excreted in part as unchanged in the feces, suggesting the excretion of this organic chlorocompound from the gut wall. These results imply that a part of PCBs may be excreted also as unchanged in the gastrointestinal tract. 

Animals; Bile/metabolism; Chromatography, Gas; Feces/analysis; Intestine, Small/*metabolism; Male; Polychlorinated Biphenyls/analysis/*metabolism; Rats; Time Factors