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Citation
Tags
HERO ID
2064236
Reference Type
Journal Article
Title
Adult hippocampal neurogenesis and mRNA expression are altered by perinatal arsenic exposure in mice and restored by brief exposure to enrichment
Author(s)
Tyler, CR; Allan, AM
Year
2013
Is Peer Reviewed?
1
Journal
PLoS ONE
EISSN:
1932-6203
Publisher
PUBLIC LIBRARY SCIENCE
Location
SAN FRANCISCO
Volume
8
Issue
9
Page Numbers
e73720
Language
English
PMID
24019935
DOI
10.1371/journal.pone.0073720
Web of Science Id
WOS:000324338200077
URL
https://dx.plos.org/10.1371/journal.pone.0073720
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Abstract
Arsenic is a common and pervasive environmental contaminant found in drinking water in varying concentrations depending on region. Exposure to arsenic induces behavioral and cognitive deficits in both human populations and in rodent models. The Environmental Protection Agency (EPA) standard for the allotment of arsenic in drinking water is in the parts-per-billion range, yet our lab has shown that 50 ppb arsenic exposure during development can have far-reaching consequences into adulthood, including deficits in learning and memory, which have been linked to altered adult neurogenesis. Given that the morphological impact of developmental arsenic exposure on the hippocampus is unknown, we sought to evaluate proliferation and differentiation of adult neural progenitor cells in the dentate gyrus after 50 ppb arsenic exposure throughout the perinatal period of development in mice (equivalent to all three trimesters in humans) using a BrdU pulse-chase assay. Proliferation of the neural progenitor population was decreased by 13% in arsenic-exposed mice, but was not significant. However, the number of differentiated cells was significantly decreased by 41% in arsenic-exposed mice compared to controls. Brief, daily exposure to environmental enrichment significantly increased proliferation and differentiation in both control and arsenic-exposed animals. Expression levels of 31% of neurogenesis-related genes including those involved in Alzheimer's disease, apoptosis, axonogenesis, growth, Notch signaling, and transcription factors were altered after arsenic exposure and restored after enrichment. Using a concentration previously considered safe by the EPA, perinatal arsenic exposure altered hippocampal morphology and gene expression, but did not inhibit the cellular neurogenic response to enrichment. It is possible that behavioral deficits observed during adulthood in animals exposed to arsenic during development derive from the lack of differentiated neural progenitor cells necessary for hippocampal-dependent learning. This study is the first to determine the impact of arsenic exposure during development on adult hippocampal neurogenesis and related gene expression.
Tags
IRIS
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
2. Initial Filter
Reviews
•
Arsenic MOA
1. MOA Literature Screening
Susceptibility Screening
3. Excluded
Other not relevant
Dragon Screened
•
Arsenic Susceptibility
5. Health Effect
Developmental Effects including Neurodevelopmental
Nervous System Effects
1. Susceptibility Literature Screening
Keyword Search
2. Excluded
MOA/Mechanistic
3. References Identified During Review
Life Stages Citation Mapping
10%-15%
•
Inorganic Arsenic (7440-38-2) [Final 2025]
PubMed
Excluded
Reviews
WOS
Excluded
Non Peer Reviewed
2. Lit Search Updates through Oct 2015
PubMed
WOS
Initial Filter
Non Peer Reviewed
Reviews
7. Other Studies through Oct 2015
MOA
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