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HERO ID
2152749
Reference Type
Journal Article
Title
Blood pressure and hypertension in relation to levels of serum polychlorinated biphenyls in residents of Anniston, Alabama
Author(s)
Goncharov, A; Bloom, M; Pavuk, M; Birman, I; Carpenter, DO
Year
2010
Is Peer Reviewed?
1
Journal
Journal of Hypertension
ISSN:
0263-6352
EISSN:
1473-5598
Volume
28
Issue
10
Page Numbers
2053-2060
Language
English
PMID
20644494
DOI
10.1097/HJH.0b013e32833c5f3e
Web of Science Id
WOS:000281867400013
Abstract
OBJECTIVE:
To determine risk factors for elevated blood pressure and hypertension in residents of Anniston, Alabama who live near a plant that manufactured polychlorinated biphenyls (PCBs).
METHODS:
A total of 758 Anniston residents had multiple measurements of blood pressure, provided information on demographic factors, medications, smoking, and exercise, and provided blood samples for determination of PCBs and total serum lipid.
RESULTS:
Rates of hypertension increased significantly (P < 0.05) with age and concentration of serum PCBs and were higher in African-Americans (n = 351) than in whites (n = 407). Hypertension also increased with BMI, but was not related to total serum lipid, sex, smoking, or exercise. Among 394 persons not on antihypertensive medication, linear regression analysis demonstrated a significant positive relation between serum PCB level and both systolic and diastolic blood pressure. After adjustment for potentially confounding variables, logistic regression gave odds ratios for the highest to lowest tertiles of total serum PCBs that exceeded 3.5 for both systolic and diastolic hypertension. When analyzed by quintiles of PCBs, the highest odds ratio was in the third quintile, suggesting a low dose effect.
CONCLUSION:
In individuals not on antihypertensive medication, serum PCB levels were significantly associated with prevalence of hypertension. Significant positive associations were also observed between PCB concentrations and systolic and diastolic blood pressure even in normotensive ranges. The strength of the relationships between PCB exposure and both hypertension and blood pressure suggests that PCB exposure may be an important contributing factor in regulation of blood pressure.
Keywords
age; BMI; diastole; hypertension; lipids; polychlorinated biphenyls; race; systole
Tags
IRIS
•
PCBs
Hazard ID: Epidemiological evidence
Litsearches
Remaining
LitSearch August 2015
Pubmed
Toxline
WoS
•
PCBs Epi Hazard ID
Health Effects
Cardiovascular
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