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HERO ID
2279473
Reference Type
Journal Article
Title
Maternal arsenic exposure and DNA damage biomarkers, and the associations with birth outcomes in a general population from taiwan
Author(s)
Chou, WC; Chung, YT; Chen, HY; Wang, CJ; Ying, TH; Chuang, CY; Tseng, YC; Wang, SL
Year
2014
Is Peer Reviewed?
1
Journal
PLoS ONE
EISSN:
1932-6203
Volume
9
Issue
2
Page Numbers
e86398
Language
English
PMID
24558361
DOI
10.1371/journal.pone.0086398
Web of Science Id
WOS:000331706700007
Abstract
Inorganic arsenic (iAs) is an established transplacental agent known to affect fetal development in animal studies. However, iAs has not been adequately studied in the general population with respect to iAs exposure during pregnancy and its impact on the health status of newborns. The aims of this study were to 1) elucidate the association between arsenic exposure and oxidative/methylated DNA damage in pregnant women, and 2) determine the association with birth outcomes. A birth cohort study of 299 pregnant mother-newborn pairs was recruited during 2001-2002 in Taiwan. We collected maternal urine samples during the 3(rd) trimester for measuring iAs and its metabolites. We used high-performance liquid chromatography/inductively coupled plasma mass spectrometry (HPLC-ICP-MS) for quantifications of the arsenic species. Liquid chromatography/tandem mass spectrometer (LC-MS/MS) was used to measure the 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and N(7)-methylguanosine (N(7)-MeG) DNA damage biomarkers. Birth outcomes were collected to assess the associations with maternal arsenic exposure and the DNA damage biomarkers. Multiple regression analyses showed that maternal urinary iAs had positive associations with the methylated N(7)-MeG (beta = 0.35, p<0.001) and oxidative 8-oxodG (beta = 0.24, p<0.001) DNA damage biomarkers, and a decreased one-minute (1-min) Apgar score (beta = -0.23, p = 0.041). Maternal N(7)-MeG was also associated with a decreased 1-min Apgar score (beta = -0.25, p = 0.042). Mutual adjustment for iAs and N(7)-MeG showed an independent and significant prediction for a decreased 1-min Apgar score of iAs (beta = -0.28, p = 0.036). Maternal iAs exposure was associated with both maternal DNA damage and adverse newborn health. Maternal N(7)-MeG levels might be a novel biomarker for monitoring fetal health related to iAs.
Tags
IRIS
•
Arsenic Hazard ID
PubMed
Excluded
Non Peer Reviewed
WOS
Excluded
Non Peer Reviewed
WOS
Excluded
Non Peer Reviewed
WOS Duplicates
WOS
Excluded
Non Peer Reviewed
WOS Duplicates
2. Lit Search Updates through Oct 2015
PubMed
WOS
Initial Filter
Non Peer Reviewed
Biomarker
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
Identified during manual review of authoritative sources
2. Initial Filter
Non peer-reviewed
5. Susceptibility Screening
Excluded/Not relevant
•
Arsenic Susceptibility
1. Susceptibility Literature Screening
Supplemental Search
2. Excluded
Not Relevant
Life Stages Citation Mapping
10%-15%
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