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Tags
HERO ID
2510803
Reference Type
Journal Article
Title
Transdermal nicotine mixed natural rubber-hydroxypropylmethylcellulose film forming systems for smoking cessation: In vitro evaluations
Author(s)
Pichayakorn, W; Suksaeree, J; Boonme, P; Taweepreda, W; Amnuaikit, T; Ritthidej, GC
Year
2015
Is Peer Reviewed?
1
Journal
Pharmaceutical Development and Technology
ISSN:
1083-7450
EISSN:
1097-9867
Volume
20
Issue
8
Page Numbers
966-975
Language
English
PMID
25162773
DOI
10.3109/10837450.2014.954725
Web of Science Id
WOS:000361338300009
Abstract
Abstract Novel film forming polymeric dispersions for transdermal nicotine delivery were prepared from deproteinized natural rubber latex (DNRL) blended with hydroxypropylmethylcellulose (HPMC) and dibutyl phthalate (DBP) or glycerin (GLY) as plasticizer. The preliminary molecular compatibility of ingredients was observed by Fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray diffractometry characterizations. All film forming polymeric dispersions were elegant in appearance and smooth in texture without agglomeration. Their pH was 7-8. In addition, their viscosity and spreadability showed good characteristics depended on HPMC and plasticizers blended. The transparent in situ dry films with good strength and elasticity were also confirmed by peeling-off. The nicotine release from them revealed an initial fast release that was similar to the release from a concentrated nicotine solution, and followed by slow release pattern from the in situ films. GLY blended formulation produced a higher amount of nicotine permeation through the in vitro pig skin than DBP blends. Ethanol mixing also enhanced nicotine permeation, but it affected the integrity of in situ films. The nicotine release and skin permeation kinetics were by a diffusion mechanism that was confirmed by the Higuchi's model. These formulations were safe without producing any severe skin irritation. However, for the stability they needed to be stored at 4 °C in tightly sealed containers.
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Database Searches
Pubmed
LitSearch Jul 2016 - Jan 2017
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WoS
LitSearch Jan 2014 - Sep 2014
PubMed
Excluded: No Primary Data on Health Effects
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