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HERO ID
2919849
Reference Type
Journal Article
Title
Association between several persistent organic pollutants and thyroid hormone levels in cord blood serum and bloodspot of the newborn infants of Korea
Author(s)
Kim, S; Park, J; Kim, HJ; Lee, JJ; Choi, G; Choi, S; Kim, S; Kim, SY; Moon, HB; Kim, S; Choi, K
Year
2015
Is Peer Reviewed?
1
Journal
PLoS ONE
EISSN:
1932-6203
Publisher
PUBLIC LIBRARY SCIENCE
Location
SAN FRANCISCO
Volume
10
Issue
5
Page Numbers
e0125213
Language
English
PMID
25965908
DOI
10.1371/journal.pone.0125213
Web of Science Id
WOS:000354543500012
Relationship(s)
is supplemented by
3123095
: Supplemental materials
Abstract
Current knowledge on adverse endocrine disruption effects of persistent organic pollutants (POPs) among newborn infants is limited and often controversial. To investigate the associations between prenatal exposure to major POPs and thyroid hormone levels among newborn infants, both cord serum or maternal serum concentrations of polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides (OCPs) were compared with five thyroid hormones in cord serum of newborn infants as well as TSH in bloodspot collected at 2 day after birth (n=104). Since cord serum thyroid hormones could be affected by those of mothers, thyroid hormone concentrations of the matching mothers at delivery were adjusted. In cord serum, BDE-47, -99, and Σchlordane (CHD) showed significant positive associations with cord or bloodspot TSH. At the same time, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) and hexachlorbenzene (HCB) showed negative associations with total T3 and total T4 in cord serum, respectively. Maternal exposure to β-hexachlorhexane (β-HCH), ΣCHD, ΣDDT, or p,p'-DDE were also associated with neonatal thyroid hormones. Although the sample size is small and the thyroid hormone levels of the subjects were within the reference range, our observation supports thyroid disrupting potential of several POPs among newborn infants, at the levels occurring in the general population. Considering the importance of thyroid hormones during gestation and early life stages, health implication of thyroid hormone effects by low level POPs exposure deserves further follow up investigations.
Tags
IRIS
•
PCBs
Hazard ID: Epidemiological evidence
Mechanistic
Litsearches
Remaining
LitSearch August 2015
Pubmed
Toxline
WoS
•
PCBs Epi Hazard ID
Health Effects
Endocrine
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