Persistent organic pollutants and promoter hypermethylation of the O(6)-methylguanine-DNA methyltransferase gene | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2920037

Reference Type

Journal Article

Title

Persistent organic pollutants and promoter hypermethylation of the O(6)-methylguanine-DNA methyltransferase gene

Author(s)

Park, SY; Kim, KS; Lee, YM; Kim, MJ; Jacobs, DR; Porta, M; Kim, DS; Lee, DH

Year

2015

Is Peer Reviewed?

Yes

Journal

Biomarkers
ISSN: 1354-750X
EISSN: 1366-5804

Volume

Issue

Page Numbers

136-142

Language

English

PMID

25585924

DOI

10.3109/1354750X.2014.1002806

Web of Science Id

WOS:000358062100006

Relationship(s)

is supplemented by 3350252 : Supplemental materials

Abstract

Promoter hypermethylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) DNA repair gene is important during carcinogenesis. We explored whether organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), were associated with hypermethylation of the MGMT gene promoter in peripheral leukocytes among 368 Koreans without cancer. Hypermethylation decreased as OCPs increased (Ptrend = 0.02), while PCB concentrations showed an inverted U-shaped association (Pquadratic < 0.01). The prevalence of MGMT promoter hypermethylation was highest within the 2nd quintile of the PCB summary score (28.4%), while it was only 2.7% in the upper 10% score. Chronic exposure to these chemicals may affect methylation of the MGMT promoter, with possibly non-monotonic dose response relationships.

Keywords

Methylation; MGMT; organochlorine pesticides; persistent organic pollutants; polychlorinated biphenyls