US EPA

3491061 

Journal Article 

Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes 

Giongo, JL; Vaucher, RA; Da Silva, AS; Oliveira, CB; de Mattos, CB; Baldissera, MD; Sagrillo, MR; Monteiro, SG; Custódio, DL; Souza de Matos, M; Sampaio, PT; Teixeira, HF; Koester, LS; da Veiga Junior, VF 

2017 

1 

Microbial Pathogenesis
ISSN: 0882-4010
EISSN: 1096-1208 

103 

13-18 

English 

27988226 

10.1016/j.micpath.2016.12.006 

WOS:000393348600003 

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85006967269&doi=10.1016%2fj.micpath.2016.12.006&partnerID=40&md5=9c14b2d200df07adf868ce0d50666f30
Exit
 

Aniba canelilla (H.B.K.) Mez, popularly known as "casca-preciosa" (precious bark), is a plant of the Lauraceae family, widely distributed in the Amazon region. Its major constituent is 1-nitro-2-phenylethane, a rare molecule in plants which is responsible for this plant's cinnamon scent. The present study aimed to report the chemical characterization of the oil extracted from Aniba canelilla using gas-chromatography/mass spectrometry and to assess its in vitro trypanocidal activity against Trypanosoma evansi, a prevalent haemoflagellate parasite that affects a broad range of mammal species in Africa, Asia and South America. The oil presented 1-nitro-2-phenylethane (83.68%) and methyleugenol (14.83%) as the two major components. The essential oil as well as both major compounds were shown to exert trypanocidal effect. Methyleugenol was slightly more active than 1-nitro-2-phenylethane. In vitro studies showed that the oil extracted from the stems of A. canelilla may be regarded as a potential natural treatment for trypanosomosis, once proven their in vivo action, may be an interesting alternative in the treatment of infected animals with T. evansi.