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3532118 
Technical Report 
EPA Report 
Toxicological review of trichloroethylene (CAS No. 79-01-6) in support of summary information on the Integrated Risk Information System (IRIS): Appendices 
U.S. Environmental Protection Agency :: U.S. EPA 
2011 
U.S. Environmental Protection Agency 
Washington, DC 
EPA/635/R-09/011F 
1269 
English 
is a supplement to 3532116 Toxicological review of trichloroethylene (CAS No. 79-01-6) in support of summary Information on the Integrated Risk Information System (IRIS)
There is substantial potential for human exposure to trichloroethylene (TCE), as it has a widespread presence in ambient air, indoor air, soil, and groundwater. At the same time, humans are likely to be exposed to a variety of compounds that are either metabolites of TCE or which have common metabolites or targets of toxicity. Once exposed, humans, as well as laboratory animal species, rapidly absorb TCE, which is then distributed to tissues via systemic circulation, extensively metabolized, and then excreted primarily in breath as unchanged TCE or carbon dioxide, or in urine as metabolites. The purpose of this Toxicological Review is to provide scientific support and rationale for the hazard and dose-response assessment in IRIS pertaining to chronic exposure to trichloroethylene. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of trichloroethylene. 
PB2012100126