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Citation
Tags
HERO ID
3532118
Reference Type
Technical Report
Subtype
EPA Report
Title
Toxicological review of trichloroethylene (CAS No. 79-01-6) in support of summary information on the Integrated Risk Information System (IRIS): Appendices
Author(s)
U.S. Environmental Protection Agency :: U.S. EPA
Year
2011
Publisher
U.S. Environmental Protection Agency
Location
Washington, DC
Report Number
EPA/635/R-09/011F
Number of Pages
1269
Language
English
URL
https://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/0199tr/Appendices_0199tr.pdf
Relationship(s)
is a supplement to
3532116
Toxicological review of trichloroethylene (CAS No. 79-01-6) in support of summary Information on the Integrated Risk Information System (IRIS)
Abstract
There is substantial potential for human exposure to trichloroethylene (TCE), as it has a widespread presence in ambient air, indoor air, soil, and groundwater. At the same time, humans are likely to be exposed to a variety of compounds that are either metabolites of TCE or which have common metabolites or targets of toxicity. Once exposed, humans, as well as laboratory animal species, rapidly absorb TCE, which is then distributed to tissues via systemic circulation, extensively metabolized, and then excreted primarily in breath as unchanged TCE or carbon dioxide, or in urine as metabolites. The purpose of this Toxicological Review is to provide scientific support and rationale for the hazard and dose-response assessment in IRIS pertaining to chronic exposure to trichloroethylene. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of trichloroethylene.
NTIS Number
PB2012100126
Tags
IRIS
•
Chloroform Combined (current)
•
Chromium VI
•
Ethylbenzene
•
Methylmercury
•
PCBs
•
Tetrachloroethylene (Perc) (Final, 2012)
•
Vanadium Inhalation
OPPT REs
•
OPPT_Perchloroethylene (Perc)_F. Human Health
•
OPPT_Trichloroethylene (TCE)_A. Summary
•
OPPT_Trichloroethylene (TCE)_C. Engineering
•
OPPT_Trichloroethylene (TCE)_D. Exposure
•
OPPT_Trichloroethylene (TCE)_E. Fate
•
OPPT_Trichloroethylene (TCE)_F. Human Health
Total – title/abstract screening
On topic
Peer review
Secondary source/ Review
PFAS
•
PFBA
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