US EPA

3749071 

Journal Article 

Increase in mouse liver weight following feeding of ammonium perfluorooctanoate and related fluorochemicals 

Kennedy, GL 

1987 

1 

Toxicology Letters
ISSN: 0378-4274
EISSN: 1879-3169 

ELSEVIER SCI IRELAND LTD 

CLARE 

BIOSIS/88/07473 

39 

2-3 

295-300 

English 

3686556 

10.1016/0378-4274(87)90245-1 

WOS:A1987L209400021 

https://search.proquest.com/docview/77845914?accountid=171501
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The weight of the mouse liver following feeding of ammonium perfluorooctanoate, ammonium perfluorononanoate, Telomer B ammonium sulfate, and WG-III was increased in a dose-dependent manner. Dietary levels of 3 ppm or greater ammonium perfluorooctanoate for either 14 or 21 days produced a significant elevation in liver weight both on an absolute and on an organ/body weight ratio basis. Similarly, ammonium perfluorononanoate produced significant increases at the lowest level tested, 3 ppm. Telomer B ammonium sulfate and WG-III also produced liver weight increases but at higher feeding levels. The striking increase in liver weight following relatively short-term exposures in mice makes this a useful screening test for comparing the liver-enlarging capacity of ammonium perfluorooctanoate and related fluorochemicals. 

Caprylates; Fluorocarbons; perfluorooctanoic acid; 947VD76D3L; Index Medicus; Dose-Response Relationship, Drug; Animals; Body Weight -- drug effects; Organ Size -- drug effects; Liver -- drug effects; Fluorocarbons -- toxicity; Liver -- pathology; Caprylates -- toxicity