Gas chromatographic determination of amides after perfluoroacylation: preparation and properties of the trifluoroacetyl and pentafluorobenzoyl derivatives | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

3856575

Reference Type

Journal Article

Title

Gas chromatographic determination of amides after perfluoroacylation: preparation and properties of the trifluoroacetyl and pentafluorobenzoyl derivatives

Author(s)

Ehrsson, H; Mellstrom, B

Year

1972

Is Peer Reviewed?

Yes

Journal

Acta Pharmaceutica
ISSN: 1330-0075

Report Number

IPA/73/068147

Volume

Suec

Issue

REF 7

Language

English

Abstract

IPA COPYRIGHT: ASHP The acylation of amides with trifluoroacetic (TFA) anhydride and pentafluorobenzoyl (PFB) chloride was studied. It was found that the TFA derivatives were formed rapidly at 20DGC., whereas the reaction with PFB chloride was considerably slower and required a trimethylamine catalyst. The PFB derivatives were found to be more stable than the TFA compounds, the latter decomposing upon dilution of the reaction mixtures. The gas chromatographic quantitative determination of phenacetin after trifluoroacetylation using a flame ionization detector is described.