Peroxisome proliferator activated receptor gamma in human placenta may mediate the adverse effects of phthalates exposure in pregnancy | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

4728508

Reference Type

Journal Article

Title

Peroxisome proliferator activated receptor gamma in human placenta may mediate the adverse effects of phthalates exposure in pregnancy

Author(s)

Huang, Y; Garcia, JM; Shu, W; Rong, H; Zhang, L; Wang, Y; Tan, Y; Lin, H; Zeng, H; Chen, JA

Year

2018

Is Peer Reviewed?

Journal

Reproductive Toxicology
ISSN: 0890-6238
EISSN: 1873-1708

Publisher

PERGAMON-ELSEVIER SCIENCE LTD

Location

OXFORD

Volume

Page Numbers

121-126

Language

English

PMID

29061543

DOI

10.1016/j.reprotox.2017.10.001

Web of Science Id

WOS:000423010500013

Abstract

Peroxisome-proliferator activated receptor gamma (PPARG) in placenta play an important role in pregnancy. Our previous study showed that it mediated the effects of phthalates on placental mRNA expression of estrogen synthetases in rats. To assess the effects of phthalate exposure on PPARG placental expression, and the contribution of PPARG to the effects of phthalates in human. 207 healthy pregnant women were recruited and their cord blood and placenta were collected upon delivery. Three phthalates, estrogens in cord blood and protein expression of PPARG in placenta were measured. Linear regression were used to analyze the relationship between phthalates exposure, PPARG expression and hormones. Phthalate levels in cord blood were positively associated with PPARG protein expression in placenta (p<0.05), whereas estrogens in cord blood were negatively associated with phthalate levels and PPARG expression (p<0.05). This study shows that PPARG in placenta may mediate the adverse effects of phthalates on pregnancy in human.