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6315759 
Journal Article 
A sensitive method for simultaneous determination of 12 classes of per- and polyfluoroalkyl substances (PFASs) in groundwater by ultrahigh performance liquid chromatography coupled with quadrupole orbitrap high resolution mass spectrometry 
Liu, S; Junaid, M; Zhong, W; Zhu, Y; Xu, N 
2020 
Yes 
Chemosphere
ISSN: 0045-6535
EISSN: 1879-1298 
Elsevier Ltd 
0045-6535 
251 
126327 
English 
is supplemented by 11374654 : Supplementary information
Per- and polyfluoroalkyl substances (PFASs) comprise a large group of chemicals with diverse physicochemical properties, which make their simultaneous determination a challenging task. A trace analytical method based on ultrahigh performance liquid chromatography-quadrupole Orbitrap high resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) was developed for simultaneous determination of 54 PFASs belonging to 12 classes in groundwater, including 24 perfluorocarbons and 30 precursors. This method provided good linearity of calibration standards (R2 > 0.99), excellent method limits of quantification (MLOQs) (0.5-250 pg/L), satisfactory matrix spiking recoveries (63%-148%), high precision (intra-day relative standard deviations (RSDs) 1.4-11.4%, inter-day RSDs 1.6-12.9%, and inter-week RSDs 2.1-12.7%), and short runtime (13 min), suitable for high throughput studies. The newly established method was successfully applied to detect PFASs in the groundwater samples collected from Hebei Province, China. Twenty PFASs were detected with the total concentration of 0.3-32.9 ng/L, indicating the contamination level similar to that in drinking water. The dominant PFASs were perfluorobutanesulfonate (PFBS), perfluorobutanoic acid (PFBA), perfluoropentanoic acid (PFPeA) and perfluorooctanoic acid (PFOA). In addition, 6:2 fluorotelomer phosphate diester (6:2 diPAP) and 6:2 fluorotelomer sulfonate (6:2 FTS) were found as the major precursors. The total PFAS concentrations were lower than the cumulative permissible limit of 70 ng/L for PFOS and PFOA recommended by the United States Environmental Protection Agency (USEPA) for drinking water in 2016. In a nutshell, this study provided a fast and sensitive method based on HRMS for the simultaneous analysis of a wide range of PFASs, present at trace levels in groundwater samples. 
Per- and polyfluoroalkyl substances (PFASs); Precursors; Groundwater; High resolution mass spectrometry; Quadrupole orbitrap 
PFAS
• Additional PFAS (formerly XAgency)
• Expanded PFAS SEM (formerly PFAS 430)
     Litsearch Update: November 2021
          PubMed
     Potassium perfluorooctanoate
     Sodium bis[2-(perfluorohexyl)ethyl] phosphate
• PFAS 150
     Literature Search Update December 2021
          PubMed
     Missing 2021 searches
     Literature Search Update December 2020
          PubMed
     Literature Search August 2019
          PubMed
     Not prioritized for screening
     Perfluorobutanesulfonate
     Perfluorobutanesulfonyl fluoride
     Perfluoropentanoic acid
• PFAS Universe
     Data Source
          Web of Science
          Pubmed
     3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctane-1-sulfonate
     6:2 Fluorotelomer sulfonic acid
     Perfluorobutanesulfonate
     Perfluorobutanesulfonic acid
     Perfluorobutanoate
     Perfluorobutanoic acid
     Perfluorooctanesulfonate
     Perfluorooctanesulfonic acid
     Perfluorooctanoate
     Perfluoropentanoate
     Perfluoropentanoic acid
     Sodium bis[2-(perfluorohexyl)ethyl] phosphate
     Perfluorooctanoic acid
• PFBA
     LitSearch: May 2019 - May 2020
          PubMed
     Scopus: April 2021
• PFBS
     Search
          PubMed
     Lit Search Update: May 2019 - May 2020
          PubMed
     Scopus: April 2021
OW - HHRAB
• PFOA (335-67-1) and PFOS (1763-23-1)
     LitSearch: Feb 2019 - May 2020
          PubMed
     Literature Search Update (Apr 2019 - Sep 2020)
          PubMed
          WOS
     LitSearch Update (Sept 2020 - Feb 2022)
          WOS