US EPA

81079 

Journal Article 

Air pollution-associated changes in lung function among asthmatic children in Detroit 

Lewis, TC; Robins, TG; Dvonch, JT; Keeler, GJ; Yip, FY; Mentz, GB; Lin, X; Parker, EA; Israel, BA; Gonzalez, L; Hill, Y 

2005 

Yes 

Environmental Health Perspectives
ISSN: 0091-6765
EISSN: 1552-9924 

113 

8 

1068-1075 

English 

16079081 

10.1289/ehp.7533 

WOS:000230941100048 

In a longitudinal cohort study of primary-school-age children with asthma in Detroit, Michigan, we examined relationships between lung function and ambient levels of particulate matter 75% were categorized as having persistent asthma. In both single-pollutant and two-pollutant models, many regressions demonstrated associations between higher exposure to ambient pollutants and poorer lung function (increased diurnal variability and decreased lowest daily values for forced expiratory volume in 1 sec) among children using CSs but not among those not using CSs, and among children reporting URI symptoms but not among those who did not report URIs. Our findings suggest that levels of air pollutants in Detroit, which are above the current National Ambient Air Quality Standards, adversely affect lung function of susceptible asthmatic children. 

Adrenal Cortex Hormones/therapeutic use; Air Pollutants/*adverse effects/analysis; Air Pollution/*adverse effects/analysis; Asthma/complications/drug therapy/*physiopathology; Child; Dust/analysis; Environmental Monitoring; Female; Forced Expiratory Volume; Humans; Male; Michigan/epidemiology; Models, Biological; Ozone/*adverse effects/analysis; Particle Size; Peak Expiratory Flow Rate; Respiratory Tract Infections/complications; Urban Population